Medications with anticholinergic side effectsįluoxetine (serotonin reuptake inhibitor)Ĭiliochoroidal effusion leading to forward displacement of lens-iris diaphragmĪlpha-adrenergic agonists can precipitate acute angle closure glaucoma by pupillary block due to pupil dilatation in individuals with innately narrow iridocorneal angles. The aim of this article is to bring this ophthalmic condition to the attention of clinicians, particularly those outside the field of ophthalmology who commonly prescribe these medications or see these patients prior to referring to ophthalmologists.įorward displacement of lens-iris diaphragm Clinicians should always review medications in patients presenting with symptoms of acute angle closure glaucoma. Most attacks occur in subjects unaware that they are at risk due to innately narrow iridocorneal angles. A PubMed search limited to the English language was conducted to find relevant literature for the purpose of this article. This article provides a basic overview of the risk factors and pathophysiologic mechanisms involved in angle closure glaucoma and focuses on drug-induced angle closure glaucoma for the non-ophthalmologist. These include adrenergic, cholinergic and anticholinergic, antidepressants, anticoagulants and sulfa-based agents.
Several types of drugs have the potential to precipitate acute angle closure glaucoma. Acute angle closure glaucoma is an ophthalmic emergency and can lead to blindness if left untreated.
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